# STOCKHOLM 1.0 #=GS AGO1_SCHPO/500-799 AC O74957.1 #=GS AGO6_ARATH/541-851 AC O48771.2 #=GS AGO4_ARATH/577-885 AC Q9ZVD5.2 #=GS TAG76_CAEEL/660-966 AC P34681.2 #=GS O16720_CAEEL/566-867 AC O16720.2 #=GS O62275_CAEEL/594-924 AC O62275.1 #=GS YQ53_CAEEL/650-977 AC Q09249.1 #=GS NRDE3_CAEEL/673-1001 AC Q21691.1 #=GS Q17567_CAEEL/397-708 AC Q17567.1 #=GS AUB_DROME/555-852 AC O76922.1 #=GS PIWI_DROME/538-829 AC Q9VKM1.1 #=GS PIWL1_HUMAN/555-847 AC Q96J94.1 #=GS PIWI_ARCFU/110-406 AC O28951.1 #=GS PIWI_ARCFU/110-406 DR PDB; 2W42 B; 110-406; #=GS PIWI_ARCFU/110-406 DR PDB; 1YTU B; 110-406; #=GS PIWI_ARCFU/110-406 DR PDB; 2BGG B; 110-406; #=GS PIWI_ARCFU/110-406 DR PDB; 1W9H A; 110-406; #=GS PIWI_ARCFU/110-406 DR PDB; 2BGG A; 110-406; #=GS PIWI_ARCFU/110-406 DR PDB; 1YTU A; 110-406; #=GS PIWI_ARCFU/110-406 DR PDB; 2W42 A; 110-406; #=GS Y1321_METJA/426-699 AC Q58717.1 #=GS O67434_AQUAE/419-694 AC O67434.1 #=GS O67434_AQUAE/419-694 DR PDB; 1YVU A; 419-694; #=GS O67434_AQUAE/419-694 DR PDB; 2F8S A; 419-694; #=GS O67434_AQUAE/419-694 DR PDB; 2F8T A; 419-694; #=GS O67434_AQUAE/419-694 DR PDB; 2F8S B; 419-694; #=GS O67434_AQUAE/419-694 DR PDB; 2NUB A; 419-694; #=GS O67434_AQUAE/419-694 DR PDB; 2F8T B; 419-694; #=GS AGO10_ARATH/625-946 AC Q9XGW1.1 AGO1_SCHPO/500-799 YLFFILDK.NSPEP.YGSIKRVCNTMLGVPSQCAISKHILQS.........KPQYCANLGMKINVKVGGIN.CSLIPKSNP....LGNVPTL.........ILGGDVYHPGVGA..........TGVSIASIVASVD.LNGCKYTAVSRSQPRHQEVIEG.MKD............IVVYLLQGFRAMTKQ.QPQRIIYFRDGTSEGQFLSVINDELSQIKEACH.......SLSPKYN..PKILVCTTQKRHHARFFIKNKSDG......................DRNGNPLPGTII...EKHVTHPYQYDFYLISHPSLQGVSVPVHYTVLHDEIQMPPDQF.QTL......CYNLCYVYARAT....SAVSLVPPVYYAHLVSNLARYQDV AGO6_ARATH/541-851 FILCILPERKTSDI.YGPWKKICLTEEGIHTQCICPIKI............SDQYLTNVLLKINSKLGGIN.SLLGIEYSYNIPLINKIPTL.........ILGMDVSHGPPGR.........ADVPSVAAVVGSKCWPLISRYRAAVRTQSPRLEMIDSLFQPIENTE..KGDNGIMNELFVEFYRTSRARKPKQIIIFRDGVSESQFEQVLKIEVDQIIKAYQ.......RLGESDV..PKFTVIVAQKNHHTKLFQAKGPE...........................NVPAGTVV...DTKIVHPTNYDFYMCAHAGKIGTSRPAHYHVLLDEIGFSPDDL.QNL......IHSLSYVNQRST....TATSIVAPVRYAHLAAAQVAQFTK AGO4_ARATH/577-885 FILCVLPDKKNSDL.YGPWKKKNLTEFGIVTQCMAPTRQPND...........QYLTNLLLKINAKLGGLN.SMLSVERTPAFTVISKVPTI.........ILGMDVSHGSPGQ.........SDVPSIAAVVSSREWPLISKYRASVRTQPSKAEMIESLVKKNGT.....EDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQFNQVLNIELDQIIEACK.......LLDANWN..PKFLLLVAQKNHHTKFFQPTSPE...........................NVPPGTII...DNKICHPKNNDFYLCAHAGMIGTTRPTHYHVLYDEIGFSADEL.QEL......VHSLSYVYQRST....SAISVVAPICYAHLAAAQLGTFMK TAG76_CAEEL/660-966 CIIVVLQS.KNSDI.YMTVKEQSDIVHGIMSQCVLMKNVSRP.........TPATCANIVLKLNMKMGGIN..SRIVADKITNKYLVDQPTM.........VVGIDVTHPTQAEM.......RMNMPSVAAIVANVD.LLPQSYGANVKVQKKCRESVVY.LLD............AIRERIITFYRHTKQ.KPARIIVYRDGVSEGQFSEVLREEIQSIRTACL.......AIAEDFR..PPITYIVVQKRHHARIFCKYQNDM.....................VGKAKNVPPGTTV...DTGIVSPEGFDFYLCSHYGVQGTSRPARYHVLLDECKFTADEI.QSI......TYGMCHTYGRCT....RSVSIPTPVYYADLVATRARCHVK O16720_CAEEL/566-867 LIVVVLPG..KTPI.YAEVKRVGDTVLGIATQCVQAKNAIRT.........TPQTLSNLCLKMNVKLGGVN.SILLPNVRPR...IFNEPVI.........FLGCDITHPAAGD.........TRKPSIAAVVGSMD.AHPSRYAATVRVQQHRQEIITD.LTY............MVRELLVQFYRNTRF.KPARIVVYRDGVSEGQLFNVLQYELRAIREACV.......MLESGYQ..PGITFIAVQKRHHTRLFAADKADQ.....................VGKAFNIPPGTTV...DVGITHPTEFDFFLCSHAGIQGTSRPSHYHVLWDDNDLTADEL.QQL......TYQMCHTYVRCT....RSVSIPAPAYYAHLVAFRARYHLV O62275_CAEEL/594-924 TFVFIITD.DSITT.LHQRYKMIEKDTKMIVQDMKLSKALSV..IN...AGKRLTLENVINKTNVKLGGSN..YVFVDAKKQL.....DSHL.........IIGVGISAPPAGTKYAM.ENKGVLNPNVIGYAYNA..QHNQEFSGDFVLNSASQDTLAP.IED............IVMHSLNEYQKFHDGGLPRRVIVYRTGTSEGNHGSIMAYEIPLARAAMR.......DFSPDIQ....LVYIVVSKDHSFRFFKPDLASLASRPQATSSTASRHSAMPAAPKAWDLNIAPGILV...DSIVTNPACKQFFLNSHITLQGTAKTPLYTVLADDAKVSMTAL.EDI......TYKLCHLHQIVG....LPTSLPTPLYVANEYAKRGRNLWN YQ53_CAEEL/650-977 DILVGIAR.EKKPD.VHDILKYFEESIGLQTIQLCQQTVDKMMGG....QGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVCSNNETLRKKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLT...NSTQLGGFTYLQTQKEYKLQKLDE............FFPKCVRSYKEHSKT.LPTRIVIYRVGAGEGNFNRVKE.EVEEMRRTFD.......KIQPGYR..PHLVVIIAQRASHARVFPSCISGN.....................RATDQNIPSGTCV...ENVLTSYGYDEFILSSQTPLIGTVRPCKYTILVNDAKWSKNEL.MHL......TYFRAFGHQVSY....QPPSVPDVLYAAENLAKRGRNNYK NRDE3_CAEEL/673-1001 TIVFGIIA.EKRPD.MHDILKYFEEKLGQQTIQISSETADKFMRD....HGGKQTIDNVIRKLNPKCGGTNFLIDVPESVGHRVVCNNSAEMRAKLYAKTQFIGFEMSHTGARTRFDIQKVMFDGDPTVVGVAYSL..KHSAQLGGFSYFQESRLHKLTN.LQE............KMQICLNAYEQSSSY.LPETVVVYRVGSGEGDYPQIVN.EVNEMKLAAR.......KKKHGYN..PKFLVICTQRNSHIRVFPEHINERG....................KSMEQNVKSGTCV...DVPGASHGYEEFILCCQTPLIGTVKPTKYTIIVNDCRWSKNEI.MNV......TYHLAFAHQVSY....APPAIPNVSYAAQNLAKRGHNNYK Q17567_CAEEL/397-708 MLVVMLAD.DNKTR.YDSLKKYLCVECPIPNQCVNLRTLAGKSKDGGENKNLGSIVLKIVLQMICKTGGA...LWKVNIPL.......KSTM.........IVGYDLYHDSTLK...........GKTVGACVSTTS.NDFTQFYSQTRPHENPTQLGNN.LTH............FVRKSLKQYYDNNDKTLPSRLILYRDGAGDGQIPYIKNTEVKLVRDACDAVTDKAAELSNKVQEKIKLAFIIVTKRVNMRILKQGSSS.......................KSAINPQPGTVV...DTTVTRPERMDFYLVPQFVNQGTVTPVSYNIIHDDTGLGPDKH.QQL......AFKLCHLYYNWQ....GTVRVPAPCQYAHKLAFLTAQSLH AUB_DROME/555-852 IVMVVMRS.PNEEK.YSCIKKRTCVDRPVPSQVVTLKVIAPRQQKP...TGLMSIATKVVIQMNAKLMGA...PWQVVIPL.......HGLM.........TVGFDVCHSPKNK...........NKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQ.MSV............NMACALRSYQEQHRS.LPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEI...YKSAGKQEG..CRMTFIIVSKRINSRYFT.............................GHRNPVPGTVV...DDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKL.QML......SYKMTHMYYNYS....GTIRVPAVCHYAHKLAFLVAESIN PIWI_DROME/538-829 LILCLVPN.DNAER.YSSIKKRGYVDRAVPTQVVTLKTTKNRSL........MSIATKIAIQLNCKLGYT...PWMIELPL.......SGLM.........TIGFDIAKSTRDR...........KRAYGALIASMDLQQNSTYFSTV.TECSAFDVLANTLWP............MIAKALRQYQHEHRK.LPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTE...YARVQLSP...PQLAYIVVTRSMNTRFFLN.............................GQNPPPGTIV...DDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKM.QKL......TYKMCHLYYNWS....GTTRVPAVCQYAKKLATLVGTNLH PIWL1_HUMAN/555-847 IVVCLLSS.NRKDK.YDAIKKYLCTDCPTPSQCVVARTLGKQQT.......VMAIATKIALQMNCKMGGE...LWRVDIPL.......KLVM.........IVGIDCYHDMTAG...........RRSIAGFVASIN.EGMTRWFSRCIFQDRGQELVDG.LKV............CLQAALRAW.NSCNEYMPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLK.......SIGRGYN..PRLTVIVVKKRVNTRFFAQSGGR.........................LQNPLPGTVI...DVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDNSGLKPDHI.QRL......TYKLCHIYYNWP....GVIRVPAPCQYAHKLAFLVGQSIH PIWI_ARCFU/110-406 GIMLVLPE.YNTPL.YYKLKSYLINS..IPSQFMRYDILSNRNL........TFYVDNLLVQFVSKLGGK...PWILNVDPEK....................GSDIIIGTGAT........RIDNVNLFCFAMVFK.KDGTMLWNEISPIVTSSEYLTY.LKS............TIKKVVYGFKKSNPDWDVEKLTLHVSG....KRPKMKDGETKILKETVE.......ELKKQEMVSRDVKYAILHLNETHPFWVMGDPN........................NRFHPYEGTKVKLSSKRYLLTLLQPYLKRNGLEMVTPIKPLSVEIVSDN..WTSEEYYHNVHEILDEIYYLSKMNWRGF....RSRNLPVTVNYPKLVAGIIANVNR #=GR PIWI_ARCFU/110-406 SS EEEEEESS.S-HHH.HHHHHHHHHTT..S-EEEEEHHHHCTSTH........HHHHHHHHHHHHHHTT-B...--EE---TTS....................STSEEEEEEEE........ESSSSEEEEEEEEEE.TTS-EEEEEE--SEEGGGHHHH.HHH............HHHHHHHHHHHTSTT---SEEEEEEES....S--S-HHHHHHHHHHHHH.......HHHHTTSS-TT-EEEEEEEEE---EEEEE-TT........................TT---STSEEEESSSSEEEEEEE-TCEEETTEEEEEEEEEEEEEEEEE-..--TTTHHHHHHHHHHHHHHHTT--TTSS....S--SS-HHHHHHHHHHHHHHHHHH Y1321_METJA/426-699 CFALIIGKEKYKDNDYYEILKKQLFDLKIISQNILWENWRKDDK........GYMTNNLLIQIMGKLGIK...YFILDSKTPYDY................IMGLDTGLGIFGN............HRVGGCTVVYDSEGKIRRIQPIETPAPGERLHLP................YVIEYLEN..KANIDMENKNILFLRDG.......FIQNSERNDLKEISK.......ELN......SNIEVISIRKNNKYKVFTSDYRI........................GSVFGNDGIFLPHKTPFGSNPVKLSTWLRFNCGNEEGLK...IN..........ESI.MQL......LYDLTKMNYSALYGEGRYLRIPAPIHYADKFVKALGKNWK O67434_AQUAE/419-694 LVIVFLEEYPKVDP.YKSFLLYDFVKRELLKKMIPSQVILNRTLKN...ENLKFVLLNVAEQVLAKTGNIP..YKLKEIEGKVDA................FVGIDISRITRDG..........KTVNAVAFTKIFNSKGELVRYYLTSYPAFGEKLTEK................AIGDVFSLLEKLGF.KKGSKIVVHRDG.......RLYRDEVAAFK...........KYGELYG..YSLELLEIIKRNNPRFFSNEKFI..............................KGYFYKLSEDSVILATYNQVY.......EGTHQPIKVRKVYGE..LPVEVL.CSQ......ILSLTLMNYSSF....QPIKLPATVHYSDKITKLMLRGIE #=GR O67434_AQUAE/419-694 SS EEEEEE---S---S.SS--HHHHHHHHHHHHTT--EEEEEHHHHHH...S-HHHHHHHHHHHHHHHTT-BS..-EES--SS--SE................EEEEEEEEEECSS..........CEEEEEEEEEEEETTS-EEEEEEEEETSSSTCHHHH................HHHHHHHHHHHTT-.-TT-EEEEEESS.......---HHHHHHHH...........HHHHHTT..-EEEEEEEE-SS---EEES-S--..............................TTEEEEETTTEEEE--S---S.......SS-B--EEEEEEE-S..S-HHHH.HHH......HHHHGGGG--TT....S--SS-TTTTTHHHHHHHHHTSSS AGO10_ARATH/625-946 LLLAILPD.NNGSL.YGDLKRICETELGLISQCCLTKHVFKI.........SKQYLANVSLKINVKMGGRN.TVLVDAISCRIPLVSDIPTI.........IFGADVTHPENGE.........ESSPSIAAVVASQDWPEVTKYAGLVCAQAHRQELIQDLYKTWQDPVRGTVSGGMIRDLLISFRKATGQ.KPLRIIFYRDGVSEGQFYQVLLYELDAIRKACA.......SLEPNYQ..PPVTFIVVQKRHHTRLFANNHRDKN...................STDRSGNILPGTVV...DTKICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENNFTADGI.QSL......TNNLCYTYARCT....RSVSIVPPAYYAHLAAFRARFYLE #=GC SS_cons EEEEEESS-S-HHC.CCHHHHHHHCCHHCHCCCEECCCCCCCCHHH...S-HHHHHHHHHHHHHHHTT-BS..-EEC--STTSSE................EECCCEEEEECCC........ESCCCEEEEEEEEEETTTSEEEEEEEEETCCCCCHHHH.HHH............HHHHHHHHHHHTTTT-TTSEEEEEECS....S..S-HHHHHHHHHHHHH.......HHHHCTTS.TCEEEEEEEECC---EEECESTT........................TT...STTEEEECTTTEEEEEEC-TCCEETTEEECCEEEEEEEEEEEES..S-CCCHHHHHHHHHHHHHHHCCGGTTTT....S--SS-CCCCCHHHHHHHHHCCCC #=GC seq_cons hllslLsc.pspsh.YtslKKhtpschsl.oQslthcslhpp.........hhphlsNlhlphNsKhGGts..hhhlshsht.......shh.........hlGhDlsHsssup..........tssoluuhluohs.ttsspahusspspspppEhlps.lp.............hltchLpsa.cpspp.hPpRIllaRDGsu-Gph.plhp.Elspl+cshc.......plstshp..PplshIllpKpppsRhFspstsp.........................t.Ns.PGThV...DstlspPpphDFaLsupsshpGTs+Ps+YpVlhD-hthos-cl.QpL......sYpLsahahpss....pslslPsPsaYA+hlAthstpph+ //